673 research outputs found
Detrended Fluctuation analysis of Bach's Inventions and Sinfonias pitches
Detrended Fluctuation Analysis (DFA), suitable for the analysis of
nonstationary time series, is used to investigate power law in some of the
Bach's pitches series. Using DFA method, which also is a well-established
method for the detection of long-range correlations, frequency series of Bach's
pitches have been analyzed. In this view we find same Hurts exponents in the
range (0.7-0.8) in his Inventions and sinfonia.Comment: 5 pages, 4 figure
Quantum Stephani exact cosmological solutions and the selection of time variable
We study perfect fluid Stephani quantum cosmological model. In the present
work the Schutz's variational formalism which recovers the notion of time is
applied. This gives rise to Wheeler-DeWitt equation for the scale factor. We
use the eigenfunctions in order to construct wave packets for each case. We
study the time-dependent behavior of the expectation value of the scale factor,
using many-worlds and deBroglie-Bohm interpretations of quantum mechanics.Comment: 19 pages, 7 figure
Signature change from Schutz's canonical quantum cosmology and its classical analogue
We study the signature change in a perfect fluid Friedmann-Robertson-Walker
quantum cosmological model. In this work the Schutz's variational formalism is
applied to recover the notion of time. This gives rise to a
Schrodinger-Wheeler-DeWitt equation with arbitrary ordering for the scale
factor. We use the eigenfunctions in order to construct wave packets and
evaluate the time-dependent expectation value of the scale factor which
coincides with the ontological interpretation. We show that these solutions
exhibit signature transitions from a finite Euclidean to a Lorentzian domain.
Moreover, such models are equivalent to a classical system where, besides the
perfect fluid, a repulsive fluid is present.Comment: 15 pages, 4 figures, to appear in PR
Quantum Stephani Universe in vicinity of the symmetry center
We study a class of spherically symmetric Stephani cosmological models in the
presence of a self-interacting scalar field in both classical and quantum
domains. We discuss the construction of `canonical' wave packets resulting from
the solutions of a class of Wheeler-DeWitt equations in the Stephani Universe.
We suggest appropriate initial conditions which result in wave packets
containing some desirable properties, most importantly good classical and
quantum correspondence. We also study the situation from de-Broglie Bohm
interpretation of quantum mechanics to recover the notion of time and compare
the classical and Bohmian results. We exhibit that the usage of the canonical
prescription and appropriate choices of expansion coefficients result in the
suppression of the quantum potential and coincidence between classical and
Bohmian results. We show that, in some cases, contrary to
Friedmann-Robertson-Walker case, the bound state solutions also exist for all
positive values of the cosmological constant.Comment: 22 pages, 19 figures, to appear in JCA
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A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.
Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in oncogenesis remains poorly understood. Here we report that a bulky glycocalyx promotes the expansion of disseminated tumor cells in vivo by fostering integrin adhesion assembly to permit G1 cell cycle progression. We engineered tumor cells to display glycocalyces of various thicknesses by coating them with synthetic mucin-mimetic glycopolymers. Cells adorned with longer glycopolymers showed increased metastatic potential, enhanced cell cycle progression, and greater levels of integrin-FAK mechanosignaling and Akt signaling in a syngeneic mouse model of metastasis. These effects were mirrored by expression of the ectodomain of cancer-associated mucin MUC1. These findings functionally link mucinous proteins with tumor aggression, and offer a new view of the cancer glycocalyx as a major driver of disease progression
Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.
Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to be the sole conduit for postreceptor signaling. Here we challenge that paradigm and show that GIV/Girdin, a guanidine exchange factor (GEF) for the trimeric G protein Gαi, is another major hierarchical conduit for the metabolic insulin response. By virtue of its ability to directly bind InsR, IRS1, and phosphoinositide 3-kinase, GIV serves as a key hub in the immediate postreceptor level, which coordinately enhances the metabolic insulin response and glucose uptake in myotubes via its GEF function. Site-directed mutagenesis or phosphoinhibition of GIV-GEF by the fatty acid/protein kinase C-theta pathway triggers IR. Insulin sensitizers reverse phosphoinhibition of GIV and reinstate insulin sensitivity. We also provide evidence for such reversible regulation of GIV-GEF in skeletal muscles from patients with IR. Thus GIV is an essential upstream component that couples InsR to G-protein signaling to enhance the metabolic insulin response, and impairment of such coupling triggers IR. We also provide evidence that GIV-GEF serves as therapeutic target for exogenous manipulation of physiological insulin response and reversal of IR in skeletal muscles
Generalized Uncertainty Principle, Modified Dispersion Relation and Barrier penetration by a Dirac particle
We have studied the energy band structure of a Dirac particle in presence of
a generalised uncertainty principle (GUP). We start from defining a modified
momentum operator and derive corresponding modified dispersion relation (MDR)
and GUP. Apart from the forbidden band within the range , being the
mass of the particle, we find the existence of additional forbidden bands at
the both ends of the spectrum. Such band structure forbids a Dirac particle to
penetrate a potential step of sufficient height (, being Planck
energy). This is also true for massless particle. Unlike the relativistic case,
a massless particle also can reflect from a barrier of sufficient height.
Finally we discuss about the Klein's paradox in presence of the GUP.Comment: 10 pages, 7 figures, LaTe
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